Naperco® (esomeprazole/naproxen)

What is Naperco® used for?

The naproxen component of Naperco® is indicated for relief of signs and symptoms of:

• Osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults.
• Juvenile idiopathic arthritis (JIA) in adolescent patients.

The esomeprazole magnesium component of this medicine is indicated to decrease the risk of developing naproxen-associated gastric ulcers.

Important notes before taking Naperco® (esomeprazole/naproxen):

Consult your doctor or pharmacist before use if you:

• Are allergic to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen or ibuprofen;
• Have a history of asthma triggered by aspirin or other NSAIDs;
• Have an active bleeding, gastrointestinal ulcers, or other bleeding disorders;
• Have heart failure or blood pressure problems;
• Have kidney or liver problems;
• Have had a recent heart attack;
• Have low blood levels of magnesium, calcium, or potassium;
• Are pregnant or planning to become pregnant;
• Are breastfeeding or planning to breastfeed.

Inform your doctor and pharmacist about all medicines you are taking, including prescription and over-the-counter medicines, herbal products, and vitamins.

Important notes while taking Naperco® (esomeprazole/naproxen):

If any of the following happen to you while you are taking this medicine, talk to your doctor straight away:

• Lose a lot of weight for no reason;
• Difficulty swallowing;
• Vomiting food or blood;
• Passing tarry stools.

If you are taking this medicine for a long time, your doctor may decide you need:

• Blood tests;
• Blood pressure monitoring;
• Measurement of magnesium levels;
• Supplementation with calcium, vitamin D, and/or vitamin B12.

Naperco® (esomeprazole/naproxen) side effects:

• Gastritis (inflammation of the stomach lining)
• Constipation
• Diarrhoea
• Taste changes
• Bloating
• Upper abdominal pain
• Urinary tract infection
• Swelling (edema)
• Headache
• Dizziness
• Upper respiratory tract infection
• Low vitamin B12 levels
• Low magnesium levels
• Asthma attacks in people who have asthma

These are not all possible side effects. Consult your doctor or pharmacist if you have any concerns.

Naperco® (esomeprazole/naproxen) drug interactions:

Tell your doctor or pharmacist if you are taking any of the following medicines:

• Aspirin or other NSAIDs
• Medicines for heart and blood vessel problems, such as clopidogrel and warfarin
• Steroid hormones
• Methotrexate
• John’s Wort
• Rifampin
• Nelfinavir, atazanavir

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

• Keep the medicine at room temperature (below than 30℃), in the original packaging, and protect it from light and moisture.
• Do not use this medicine after the expiry date.
• Keep out of the sight and reach of children.
• Throw away unused or expired drugs. Check with your pharmacist if you have questions about the best way to throw out drugs.