Crinone 8% Vaginal Gel



Product Description:

Crinone® is a vaginal progesterone gel formulation used for progesterone supplementation of the luteal phase as part of an ART procedure1. Progesterone helps to prepare the lining of the uterus to receive a fertilized egg. Crinone® is made by Merck Pharmaceuticals.

Product Introduction

What Crinone is and what it is used for?

The full name of your medicine is Crinone 8% w/w vaginal gel. In this leaflet, the shorter name Crinone is used. Crinone contains a hormone called progesterone. When the gel is inserted into your vagina, the progesterone is slowly released into your bloodstream throughout the day. Crinone is used to give you extra progesterone in the treatment of infertility due to incorrect levels of progesterone during the menstrual cycle or when you are having an assisted fertility procedure. This is to help you get pregnant. You may also be asked to continue using Crinone to support your new pregnancy.


What do you need to know before you use Crinone?

 Do not use Crinone

  • if you are allergic to the active substance or any of the other ingredients of this medicine (listed in section 6).
  • if you have unexplained vaginal bleeding
  • if you have porphyria (an inability to break down certain substances (porphyrins) in your blood that is passed down in families)
  • if you have or think you might have cancer in your breasts or genital organs • if you have ever had a blood clot due to swollen veins (thrombophlebitis), a blocked blood vessel (thromboembolic disorder), or a stroke
  • if you are pregnant but your baby has died inside of you (missed abortion).


Do not use Crinone if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before using this medicine.


Warnings and precautions

Talk to your doctor or pharmacist before using Crinone if any of the following apply to you. They may want to monitor you more closely during treatment:

  • if you have liver or kidney problems
  • if you have heart problems ordiabetes
  • if you have asthma
  • if you have epilepsy or often get migraines
  • if you have ever had depression.


 Tell your doctor if you get any unexpected bleeding so that they can investigate the cause of this.


Pregnancy and breast-feeding

  • Crinone is not normally used during pregnancy. However, if you used Crinone to help you get pregnant, you may be asked to continue using it to support your new pregnancy.


  • The use of Crinone during breastfeeding is not recommended.



How to use

This medicine is only for use in your vagina using the pre-filled applicator supplied in the pack. Before using the applicator, please read all of the instructions below.


After using your applicator

Throw away the applicator, including the small amount of gel that is left inside. Use each applicator only once. Crinone gel can stay in your vagina for several days. You may get a beige to brownish clumpy or cloudy white discharge during this time. This is nothing to worry about.


How to store Crinone

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the cartons and the wrapper after ‘EXP’. The expiry date refers to the last day of that month.
  • Do not store above 25°C.
  • Use each applicator only once. Any gel left in the applicator must be thrown away.
  • Do not throw away any medicines via wastewater or household waste.

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